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Lancet (2016) 387:67990

Consequently, the magnitude of weight loss benefit in multi-agonist therapies has shown dependence on glucagon activity: a balanced ratio of GLP-1 and glucagon receptors co-agonism achieves maximal weight loss without hyperglycaemia in contrast to dual-agonists with lower glucagon receptor potency or enhanced glucagon receptor activity [89]

Check for food sensitivities and avoid trigger foods: Food sensitivities can be both a root cause or exacerbating factor for Hashimotos, and a root cause for constipation

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